AHK-CU 10vials/box

Basic Information

Full Name: L-Alanyl-L-histidyl-L-lysine copper (II) complex (Alanyl-histidyl-lysine copper complex)

Aliases: AHK-Cu, Copper Tripeptide-3, Tripeptide-10 Copper

Sequence: Ala-His-Lys-Cu²⁺ (1:1 stable chelation, histidine imidazole ring as the core coordination site)

Molecular Weight: ≈412-419 Da

CAS: 767286-83-9 (mainstream), 89030-95-5

Dosage Form: Lyophilized powder (5mg/10mg), solution (1-5ppm)

II. Core Mechanism (Hair Follicle Targeting + Copper Ion Delivery)

Targeting Hair Follicles: The AHK sequence has a strong affinity for dermal papillary cells (DPCs), precisely targeting the hair follicle's "growth command center."

Copper ion delivery: Stable chelation of Cu²⁺, efficiently delivered to hair follicles and skin, activating key enzymes such as lysyl oxidase and tyrosinase.

Growth signaling: Stimulates VEGF (vascular endothelial growth factor), improving scalp blood supply and nutrient delivery.

Inhibits TGF-β1, delaying the transition of hair follicles from the anagen (growth) to the catagen (regression) phase.

Increases the Bcl-2/Bax ratio, reducing hair follicle cell apoptosis and prolonging the anagen phase.

Repair and anti-aging: Promotes fibroblast proliferation and collagen/elastin synthesis, repairing the scalp barrier and addressing skin aging.

III. Core Efficacy (Scientific Research/Cosmetic Data)

1. Hair Growth (Main Function)

Prolonged anagen phase: Significantly prolongs the anagen phase of hair follicles, reducing telogen (resting) phase hair loss.

Promotes hair follicle proliferation: Stimulates dermal papilla cell division, activating dormant hair follicles.

Improved blood supply: Upregulates VEGF, increasing scalp microcirculation and improving nutrient supply.

Suitable for: Androgenetic alopecia, telogen effluvium, postpartum hair loss, and thinning hair due to scalp aging.

2. Scalp and Skin Repair

Barrier Repair: Promotes the proliferation of keratinocytes and fibroblasts, repairing damaged scalp/skin.

Anti-aging and Firming: Boosts collagen/elastin, improving fine lines, sagging, and photoaging.

Anti-inflammatory and Soothing: Reduces scalp inflammation, sensitivity, and redness.

IV. Usage and Dosage

1. Reconstituted (lyophilized powder)

Soluble: 0.9% benzyl alcohol antibacterial water (BAC Water) or sterile water

Concentration: 1-5 ppm (1-2 ppm is commonly used for hair growth; 0.5-1 ppm for skin care)

Instructions: Slowly pour along the bottle wall, gently swirl to mix, do not shake vigorously.

Storage: Refrigerate at 2-8℃ after reconstitution.