Thymalin 10vials/box

Basic Product Information

Full Name: Thymalin (Thymic Peptide Complex)

CAS Number: 79621-14-0 (Natural Extract); 84006-44-2 (Core Active Dipeptide EW)

Source / Ingredients:

Natural Type: A mixture of polypeptides extracted from calf thymus tissue using mild acid extraction. The core active ingredients are EW (Glu-Trp, Thymogen), KE (Lys-Glu, Vilon), and EDP (Glu-Asp-Pro, Crystagen).

Synthetic Type: A standardized synthetic dipeptide with **L-Glu-L-Trp (EW, 333.34 Da)** as its core.

Appearance: White/off-white sterile lyophilized powder with good water solubility.

Purity: HPLC ≥98%, endotoxin-free, research-grade.

Research Positioning: A thymus-targeted immunomodulator, focusing on immune homeostasis reconstruction, aging immune reversal, and immune protection against radiotherapy and chemotherapy.

II. Core Mechanism of Action (Dual Pathway of Gene Regulation + Immune Remodeling)

1. Epigenetics and Gene Expression Regulation (Core Mechanism)

Active short peptides (EW/KE/EDP) directly bind to specific sequences in the minor groove of DNA (GGAG/AGAC) and histones, regulating the transcription of immune-related genes and non-mutantly altering gene expression patterns.

Upregulating Foxn1 (a core transcription factor in thymic epithelial cells) and TSLP/IL-7 reverses thymic atrophy and restarts T cell production.

Inhibiting the NF-κ B pathway and downregulating pro-inflammatory factors such as IL-1β, IL-6, and TNF-α, balancing immune inflammation.

2. Hematopoietic Stem Cell and T Cell Maturation Driver

Reducing the stem cell marker CD44/CD117 promotes the directed differentiation of hematopoietic stem cells into T lymphocytes.

Significantly increasing the expression of mature CD28⁺ T cells (up to +6.8-fold), rebuilding the CD4⁺/CD8⁺ T cell pool.

Activating NK cell activity and quantity, enhancing innate immune surveillance and anti-tumor capabilities.

3. Anti-apoptosis and Antioxidant Effects of Immune Cells

Reduce oxidative stress damage to lymphocytes and decrease apoptosis induced by radiotherapy, chemotherapy, and aging.

Upregulate heat shock proteins, enhance cellular stress tolerance, and protect bone marrow hematopoietic function.

III. Core Research Applications

Aging Immune Reversal (Immunoaging Model): Intervention for thymic degeneration, recurrent infections, and immunodeficiency in the elderly, restoring naive T cell output.

Radiotherapy/Chemotherapy Immune Protection: Alleviating leukopenia, lymphocyte depletion, and long-term immunosuppression caused by chemotherapy/radiotherapy.

Viral Infection Immune Reconstitution: Immune repair for respiratory viruses, hepatitis, and chronic persistent infections, enhancing antiviral responses.

Tumor Immunotherapy Combined Research: Single-drug or combined immune checkpoint inhibitors to reshape the tumor microenvironment and eliminate immune escape.

Autoimmune Balance: Regulating chronic low-grade inflammation and immune dysregulation for in vitro controlled experiments on autoimmune diseases.

Anti-aging and Lifespan Research: Intervening in telomere-related genes to delay cellular aging and explore mechanisms for maintaining health in the elderly.

IV. Reconstitution and Storage Specifications

Reconstitution

Solubilizers: Sterile water for injection, 0.9% physiological saline, 0.6%... Acetic acid aqueous solution

Handling: Gently invert to dissolve; avoid vigorous shaking to prevent peptide chain breakage.

Storage: Unopened lyophilized powder: Short-term refrigeration at 2-8℃; long-term storage at -20℃, sealed and protected from light; shelf life ≥24 months.