Ipamorelin 10Vials/box

Basic Information

Full Name: Ipamorelin Acetate

CAS: 170851-70-4

Structure: Pentapeptide (5 amino acids), Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂

Molecular Weight: 711.86 Da

Appearance: White lyophilized powder

II. Core Mechanism of Action

Targeted Receptor: Selectively activates pituitary GHS-R1a (ghrelin receptor), triggering GH vesicle release.

High Selectivity: Does not significantly increase cortisol, prolactin, or ACTH, unlike GHRP-2/GHRP-6, offering higher safety.

Pulse Release: Mimics physiological GH pulses, preserving in vivo negative feedback (somatostatin regulation), making desensitization less likely.

Downstream Effects: GH → Liver secretes IGF-1, mediating protein synthesis, lipolysis, and tissue repair.

III. Core Efficacy (Research/Clinical Applications)

1. Metabolism and Body Composition

Increases lean body mass, reduces visceral fat, and optimizes body fat percentage.

Improves insulin sensitivity and supports blood glucose homeostasis.

2. Exercise and Injury Recovery

Accelerates muscle repair, improves post-exercise recovery speed, and reduces muscle breakdown.

Promotes bone density improvement, aiding in fracture/post-operative rehabilitation.

3. Anti-aging and Sleep

Improves skin elasticity, promotes collagen synthesis, and reduces wrinkles.

Present-night administration enhances the nighttime GH peak, improves deep sleep, and reduces awakenings.

4. Endocrine Optimization

Improves age-related GH decline, enhancing energy and overall vitality.

IV. Dosage and Administration (Commonly Used in Adults)

Time of Administration:

30-60 minutes before bedtime (preferred for enhancing nighttime GH pulses)

Early morning on an empty stomach / Before training (optional, to boost daytime metabolism)

Dosage:

Single dose: 100-300 mcg

Frequency: 1-3 times daily (commonly 2 times: before bedtime upon waking)

Total daily dose: 200-600 mcg

Treatment duration: Effective in 3-6 months, requires coordination with diet, exercise, and sleep.

V. Dissolving and Storage

Reconstitution: Gently dissolve in sterile water for injection/physiological saline, avoiding vigorous shaking.

Dry powder: Refrigerate at 2-8℃, protected from light; long-term storage at -20℃.