KPV 10vials/box

Basic Information

Full Name / Aliases: KPV, Lys-Pro-Val, α-MSH (11-13), Tripeptide-36, Ac-KPV-NH₂ (acetylated modified type)

CAS: 67727-97-3 (free type)

Source: C- terminal core fragment of human α-melanocyte-stimulating hormone (α-MSH), without melanin-promoting/pigmentation activity

Dosage Form: Lyophilized powder

II. Core Mechanism (Three Major Advantages)

1. Precise Inhibition of NF-κ B (Anti-inflammatory Core)

Stable I κB-α, blocks p65 nuclear translocation, inhibiting pro-inflammatory factors such as TNF-α, IL-1β, IL-6, and IL-8 from the source.

Independent of melanocortin receptors (MC1R/3R/4R), no pigmentation, no appetite/sexual desire interference.

Simultaneously inhibits the MAPK pathway, doubly blocking inflammatory signals.

2. Oral Bioavailability (Rare Peptide Characteristics)

Passes through the intestinal PepT1... The transporter directly enters the intestinal epithelium/immune cells, and is effective orally (most peptides are only effective by injection).

Strong intestinal targeting, with outstanding effects on IBD, leaky gut, and colitis.

3. Dual antibacterial and repair effects:

Directly inhibits pathogenic bacteria such as Staphylococcus aureus and Candida albicans.

Repairs the intestinal and skin barriers, reducing "leaky gut" and skin sensitivity.

III. Core Efficacy (Research Application)

1. Anti-inflammatory (strongest):

Acute/chronic inflammation: arthritis, colitis, dermatitis, postoperative inflammation.

Immune regulation: Does not suppress overall immunity, only downregulates excessive inflammation, suitable for adjuvant immune support.