MOTS-C 10vials/box

Basic Information

Full Name: Mitochondrial Open Reading Frame of the 12S rRNA Type-C (Mitochondrial 12S rRNA Open Reading Frame C- type peptide)

CAS: 162758-54-6

Structure: A small polypeptide of 16 amino acids, α-helix structure, encoded by mitochondrial DNA (mtDNA) (non-nuclear DNA)

Appearance: White lyophilized powder, well-soluble in water

II. Core Mechanism of Action (Folate-AICAR-AMPK Pathway)

Activation of AMPK (metabolic master switch)

Inhibition of folate cycle, accumulation of AICAR (endogenous AMP analogue), directly activating AMPK

Mimetic metabolic signals of exercise/fasting, triggering systemic energy reprogramming

Mitochondrial-nuclear signaling

During metabolic stress, MOTS-c translocates from mitochondria to the nucleus, regulating nuclear gene expression and enhancing cellular resilience

Downstream cascade effects

Enhanced glucose uptake (GLUT4) Translocation, improving insulin sensitivity)

Promoting fat oxidation (fat burning, reducing visceral fat)

Stimulating mitochondrial biosynthesis (enhancing energy production and endurance)

Inhibiting mTOR, promoting autophagy, delaying cell aging

III. Core Efficacy (Research/Application)

1. Metabolic Health (Strongest)

Improving insulin resistance: Enhancing insulin sensitivity, lowering fasting blood glucose and glycated hemoglobin (HbA1c)

Powerful fat burning: Promoting the browning of white adipose tissue, increasing thermogenesis, reducing body fat (especially visceral fat), and preserving muscle

Optimizing blood lipids: Lowering triglycerides and LDL, increasing HDL

2. Athletic Performance and Recovery

Enhancing endurance: Increasing mitochondrial numbers, improving aerobic capacity, and delaying fatigue

Accelerating recovery: Reducing post-training inflammation, shortening DOMS, and promoting muscle repair

Anti-fatigue: Eliminating afternoon energy collapse and enhancing sustained energy

3. Anti-aging and Longevity

Delaying cell aging: Activating autophagy, reducing oxidative stress, and protecting telomeres

Improving bone density: Regulating osteogenic/ Osteoclastolysis balance, preventing osteoporosis

Cardiovascular protection: Improves vascular endothelial function, reduces the risk of atherosclerosis

4. Other:

Anti-inflammatory: Reduces pro-inflammatory factors (TNF-α, IL-6), increases anti-inflammatory factors

Neuroprotective: Improves brain metabolism, supports cognitive function